Covid-19 Cepiva

AndY1

Guru
Osebje foruma
18. sep 2007
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Prvi stavek tvoje spletne strani se glasi:

"Dr. Malone is the inventor of mRNA vaccines"

Podčrtaj "technology"
Sem podčrtal :zmaga:

Drugače pa ja, imate prav. Nekje piše z, nekje pa brez:

It all started when…​

Dr. Malone is the inventor of mRNA vaccines (and DNA vaccines). He also discovered lipid mediated and naked RNA transfection technologies.

It all started when he was at the Salk Institute in 1987 and 1988. There, he pioneered in-vitro RNA transfection and also in-vivo RNA transfection (in frog embryos, as well as mice).

This resulted in his seminal paper: Cationic liposome-mediated RNA transfection RW Malone, PL Felgner, IM Verma. Proceedings of the National Academy of Sciences (PNAS) 86 (16), 6077-6081
His filed patent and disclosures from the Salk included in-vivo RNA transfection and also methods for mRNA stabilization - now being claimed as invented by others. These are available for review.
His research was continued at Vical in 1989, where the first in-vivo mammalian rat experiments were designed by him. The mRNA, constructs, reagents were developed at the Salk institute and at Vical by Dr. Malone, this included dosing amounts for the in-vivo experiments. RNA and DNA were sent to Dr. Jon Wolff via Fedex. Dr.Wolff at the University of Wisconsin injected mice and rats. The initial patent disclosures for RNA and DNA vaccination were written by Dr. Malone in 1988-1989. Dr. Malone was also an inventor of DNA vaccines in 1988 and 1989.

This body of work resulted in over 10 patents and numerous publications, yielding about 7000 citations for this work. The paper was the first showing data for DNA and RNA side by side for in-vivo (the first paper for in-vivo DNA):
Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles, is the result of that work.
In 1989, research was performed that gave rise to the 10+ groundbreaking patents on mRNA vaccination, all with a priority date of March 3, 1989. This is the same priority date as the Salk Patent application, showing that the two institutions were working together (without Robert’s knowledge). These patents are the first published research on mRNA vaccination. The titles and links to the patents are listed in the documents below. These patents have proof of principle experiments on mRNA vaccines - that clearly document that the invention worked and that these are the first experiments showing this.

Vical was to license the Salk Technology. Instead, they hired Robert’s thesis advisor from the Salk and soon after, the Salk dropped the patent and Vical never pursued a license from the Salk. Due to an employee contract with Vical, this stopped Robert from working in the field commercially for a decade. Vical claimed all the Salk research happened at Vical and sent a cease and desist letter.

Dr. Malone carried on his research into mRNA vaccination during the 1990s, culminating in a mucosal patent that was issued in 2000. He also helped revolutionized the field of cationic liposomes for the use in RNA vaccinations. This work was so far ahead of its time, that only now is the world turning to mucosal mRNA vaccination as a method of immunization. For a listing of some of his work, see the publications at the end of this page.

Scientifically trained at UC Davis, UC San Diego, and at the Salk Institute Molecular Biology and Virology laboratories, Dr. Malone received his medical training at Northwestern University (MD) and Harvard University Medical School (Clinical Research Post Graduate) , and in Pathology at UC Davis, He has almost 100 peer-reviewed publications, and has been an invited speaker at about 50 conferences.
 

AndY1

Guru
Osebje foruma
18. sep 2007
22.082
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R0KY

Guru
30. apr 2010
3.830
715
113
Lol, te so cist objektivni ja:
the outset, we note that this scientist and physician is part of the advisory board for TrialSite News, and we concede that our relationship with him makes us more inclined to trust him
 

luka51

Guru
16. avg 2007
14.394
5.674
113
Vem, to je že pisalo na očetovem potrdilu, ko je bil cepljen januarja.
Ena fora mora biti, ker je edini pogoj, da J&J in Moderna še obržita EUA to, da ni zadosten availability (na kar je opozoril johan_blond). Količina Pfizerjevega cepiva je pa v ZDA več kot zadostna.




Taka je viala EUA cepiva:


Na novi, odobreni viali pa očitno namesto Pfizer-BioNTech piše Comirnaty:


Torej se grejo switch&bait. Odobritev so dobili za Comirnaty vialo in ker jih je "premalo", EUA cepivom ne poteče EUA - jasno, tudi EUA Pfizer cepivu, s tem, da se bodo sklicevali, da je cepljenje obvezno, vendar obvezno cepljenje velja le za Comirnaty vialo, skušali pa te bodo cepiti z EUA vialo.
To so po hitri pošti poslali iz usa cepivo? Ker včeraj je na flaši v Slo pisalo Comirnaty
 

Fly

Guru
21. jul 2007
2.636
505
113
Zanimivo,
mi vaxerji pa ravno antivaxerje vidimo kot ovce. Bomo videli kdo bo imel na koncu “prav”. Pri meni se vse neha ko večina začne vleči not še 5g čipe in trorije zarote. Na žalost, nekaj normalnim antivaxerjem, taki porušijo vso kredibilnost še njim.
 

D_K

Duplek
24. sep 2007
3.037
832
113
Jaz drugače najraje sprelmljam podatke Izraela, ker so pač tam najprej začeli masovno cepit (niso pa dosegli žejenega cilja)
Vse kar je važno pri tej pandemiji so podatki na veliki množici ljudi in to v tem trenutku že imamo.


Trenutna slika na 100k za paciente s težjim potekom 60+:

1629919620952.png


vir (stran), ki je je potrebno prevesti z google translate:

in še razlaga zakaj se podatki gledajo na 100k prebivalcev.
 

Ytbnd

Guru
2. mar 2010
16.791
5.918
113

Pfizer CEO says vaccine-resistant strain of COVID is 'likely' to emerge - but claims pharmaceutical giant will develop new shot to tackle it within 95 days​

//Še dobro da sedaj cepijo s cepivom za lansko alfo.


Po softveru (Adobe, ms office live, sap cloud)
Pfizer v big pfarma kot prvi uvaja "subscription services" za cepljenčke.
 
  • Všeč mi je
Reactions: AndY1

p4pe

Guru
24. feb 2010
1.603
997
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48
KR

Pfizer CEO says vaccine-resistant strain of COVID is 'likely' to emerge - but claims pharmaceutical giant will develop new shot to tackle it within 95 days​

//Še dobro da sedaj cepijo s cepivom za lansko alfo.


Po softveru (Adobe, ms office live, sap cloud)
Pfizer v big pfarma kot prvi uvaja "subscription services" za cepljenčke.
Zakaj je treba tebi žalit vse cepljene z ovcami, cepljenčki, idioti, itd. Konc koncev, kaj tebe sploh briga, če se je kdo cepil ali ne. A te kateri od cepljenih tiši v cepljenje oziroma ovira pri čemerkoli? Res ne zastopim, zakaj ste tako nastrojeni. Ne se cepit pa basta, cepljenih pa tud ni treba žalit in jih pustite na miru. Live and let live. Oziroma po antivaxersko za cepljene: Live and let die. :norec: :nazdravje:
 

Ted

Guru
8. sep 2007
1.712
588
113
Kako vas lepo trolajo, kot ovce v ograji


Kako točno nas trolajo?

WHO Director-General Tedros Adhanom Ghebreyesus pleaded with countries during a news conference in Hungary “to share what can be used for boosters” to help other places “increase their first and second vaccination coverage,” according to reporters at the event.

He argued that wealthy nations stockpiling the vaccine increases the risk that stronger variants will develop in countries with low inoculation rates.
Not only could the hyper infectious delta variant become “more virulent,” but “more potent variants could also emerge” if the virus gets “the chance to circulate in countries with low vaccination coverage,” Ghebreyesus warned.
 

LjuboB

Fizikalc
15. mar 2010
432
197
43
Logarjeva laže?

Včeraj je bilo po TV, da ima švedska 90% precepljenost.

Pri cepljenju slabši od ostalih Logarjeva ocenjuje, da smo pri cepljenju pozni, saj smo slabši od številnih evropskih držav. "Zanimivo je, da smo dolgo poslušali o tem, kako je na Švedskem, zdaj ko je tam precepljenost blizu 90-odstotna, pa primerjava s Švedsko ni več tako popularna," je še dejala Logarjeva.

Več na: https://www.zurnal24.si/slovenija/p...bodo-zaostrovali-ko-bo-epidemija-rasla-372092 - www.zurnal24.si


Če pa gledamo covid-19 vaccination trackerje, pa je podatek za švedsko nekaj čez 50%.

Npr.

Kaj je zdaj resnica?
 

AndY1

Guru
Osebje foruma
18. sep 2007
22.082
4.080
113
To so po hitri pošti poslali iz usa cepivo? Ker včeraj je na flaši v Slo pisalo Comirnaty
Nič ne bluzim. V ZDA imajo takole:


Na njihovih (v ZDA) vialah (flaškah) do zdaj ni pisalo Comirnaty. Z odobreno različico pa piše Comirnaty, na EUA viali pa piše Pfizer-BioNTech. To piše tudi v tekstu FDA odobritve.